Regarding the maintenance of CD8+ Trm cells in the liver, we found that Il2rb, a subunit of IL-15 receptor, is highly expressed in RES CD8+ Trm cells, whereas its neutralization during NASH resolution diminishes CD8+ Trm cells and prevents fibrosis resolution, underscoring the requirement for IL-15 in the maintenance of CD8+ Trm cells during NASH resolution. This evidence concerns the gene CD8A and metabolic dysfunction-associated steatohepatitis.