Since RES Trm cells highly expresses IL-15 receptor genes (Il15ra, Il2rb) (Figs. 3e and 4d), we antagonized IL-15 signaling to investigate the role of IL-15 in the maintenance of CD8+ Trm cells and the subsequent effect on NASH resolution (Fig. 6a). Here, IL2RB is linked to metabolic dysfunction-associated steatohepatitis.