Although mice transplanted with HFHC CD8T cells demonstrated a modest reduction in liver inflammation and fibrosis, RES CD8T cells achieved a significant superior effect (Fig. 5d–h) partly by inducing cell death of HSCs with less contribution of macrophages (Fig. 5i–k), underpinning a role for RES CD8+ Trm cells in suppressing NASH progression, in addition to their role in NASH resolution. The gene discussed is CD8A; the disease is metabolic dysfunction-associated steatohepatitis.