Consistently, the proportion of CD8+ Trm cells was significantly increased in the liver of fibrosis-resolved mice compared to that in the liver of MCD mice (Supplementary Fig. 7e), while ablation of CD8+ T cells negated the resolution of fibrosis (Supplementary Fig. 7f–i), reinforcing the role of CD8+ T cells in NASH resolution. This evidence concerns the gene CD8A and metabolic dysfunction-associated steatohepatitis.