Here in our study, we exclude the involvement of the cAMP-MAPKs pathway and the Akt/mTOR pathways in the regulation of CXCR5-mediated endothelial inflammation, confirming that coupling of SNO-GNAI2 to CXCR5 specifically regulates Hippo-YAP signaling in condition of diabetes-accelerated atherosclerosis. This evidence concerns the gene CXCR5 and diabetes mellitus.