To investigate the role of S-nitrosylation of GNAI2 in diabetes-accelerated atherosclerosis, we detected SNO-GNAI2 in coronary artery samples of diabetic patients with coronary artery disease (CAD-DM) and found a significant increase in SNO-GNAI2 rather than total-GNAI2 level, compared to patients with CAD (Fig. 1b). This evidence concerns the gene GNAI2 and atherosclerosis.