Moreover, the binding sites of eight TFs in cancer cell lines (data available from ENCODE; the data source is provided in Supplementary Data 20) largely overlapped with predicted enhancers (Supplementary Fig. 18a); dozens to hundreds of common or LNC-specific gained enhancers that were associated with important oncogenesis- or metastasis-related genes, such as ZXDC, CTNNB1, CXCR5, CCND2, STAT3, and SNAI1, were bound by IRF2, RXRA, RELA, or ZEB1 (Supplementary Fig. 18b and Supplementary Data 20). This evidence concerns the gene STAT3 and cancer.