We also identified six genes (KHDRBS2, IQSEC1, ARHGEF1, ARID5A, IRX5, and TMC6) that were activated in metastatic cancers in two of the three cancer types (Supplementary Fig. 15d) and might be associated with metastatic traits. The gene discussed is IQSEC1; the disease is metastatic malignant neoplasm.