By elucidating core transcriptional regulatory circuitries from the set of gained enhancers, we identified several key TFs, including RXRA, NFE2L2, IRF2, RELA, etc., involved in cell growth and migration (Fig. 4f, g), some of which were also revealed to have tumor-promoting functions in ependymoma and RCC25,26. The gene discussed is NFE2L2; the disease is ependymoma.