Then, cell growth was assessed in TE1 esophageal cancer cells expressing the control shRNA or shRNAs targeting these 12 TFs, showing that the depletion of IRF2, RXRA, RELA, SOX12, and NFATC2 resulted in a significant decrease in cell proliferation and that the knockdown of ETS1 (with shRNA2), ZEB1, TCF3, and NFE2L2 led to a modest decrease in cell growth (Fig. 4f and Supplementary Fig. 17a). The gene discussed is IRF2; the disease is esophageal cancer.