For example, neighboring regions of CCND1, CLUAP1, and MTMR8 showed a significant gain of promoter elements, enhancers, and SEs in cancer tissues, and loss of promoter elements, enhancers, and SEs was observed in TFAP2B, MAU2, and EHF, accompanied by transcriptional activation (CCND1) or repression (EHF) (Fig. 1h and Supplementary Figs. 6i, 7). This evidence concerns the gene TFAP2B and cancer.