PDE4B and cancer: To assess the functions of these gained SE-linked putative targets in cancer metastasis, we performed wound healing assays upon inhibitors treatment and found that nearly all of these applied inhibitors showed strong (HSP90AA1, PDE4B, and BCL2) or weak (ANO1, CCR3, CCND1, and CXCR4) suppressive effects on cell migration (Fig. 5d and Supplementary Fig. 19g).