RXRA and cancer: Moreover, the binding sites of eight TFs in cancer cell lines (data available from ENCODE; the data source is provided in Supplementary Data 20) largely overlapped with predicted enhancers (Supplementary Fig. 18a); dozens to hundreds of common or LNC-specific gained enhancers that were associated with important oncogenesis- or metastasis-related genes, such as ZXDC, CTNNB1, CXCR5, CCND2, STAT3, and SNAI1, were bound by IRF2, RXRA, RELA, or ZEB1 (Supplementary Fig. 18b and Supplementary Data 20).