Notably, the inhibitory effects on cell proliferation (Supplementary Fig. 20a–d) and proapoptotic effects (Supplementary Fig. 20e, f) of HSP90AA1 inhibitor and PDE4B inhibitor were perfectly validated in another two ESCC lines (KYSE30 and KYSE150). The gene discussed is HSP90AA1; the disease is esophageal squamous cell carcinoma.