Therefore, we selected the genes for which the nearby enhancers were pre-activated (such as SORL1, BCL2, KLHL6, and CLDN3) or pre-silenced (such as MAPK6, ETS2, LCN2, and LGALSL) before transcriptional alterations in EC samples, and considered that these enhancers or their associated genes might be the priming factors for the initiation of cancer metastasis-related processes (Supplementary Fig. 11 and Supplementary Data 10). This evidence concerns the gene CLDN3 and cancer.