Relative to the normal esophageal epithelium, 392 (46.3%) and 494 (52.1%) cancer-specific SEs were recovered in the EC and LNC H3K27ac profiles, respectively, and these SEs were enriched with cancer-associated genes or oncogenes, such as CCND125,26, CWH43, ANO1, and CXCR4 (Fig. 1f, g and Supplementary Fig. 7). Here, CXCR4 is linked to cancer.