APOE and Alzheimer disease: In addition, we found that genes within the top EWASplus regions have evidence of physical interaction with known AD genes or AD GWAS loci (Supplementary Fig. 6) (e.g., PRKAG2 and TNS3 interact with APOE, CLU, APP, PSEN1/2, and RIN2 and RIN3 interact with BIN1).