Moreover, aberrant expression of FGFR1 is detected in ALDHhigh (ALDH + ) pancreatic cancer cells and enhance the tumorigenesis and CSCs(cell stem cell)-like phenotype of PDAC (pancreatic ductal adenocarcinoma) cells with increased expression of Oct4 (POU class 5 homeobox 1), Sox-2 (SRY-box transcription factor 2), Nanog (Nanog homeobox), and c-Myc (MYC proto-oncogene, bHLH transcription factor), but targeting FGFR signalling with the selective FGFR1 inhibitor, PD173074 inhibited the proliferation and self-renewal of the panCSCs [15]. This evidence concerns the gene POU5F1 and familial pancreatic carcinoma.