To investigate the chemoresistance role of GLT8D2 in ovarian cancer progression, we firstly examine the protein expression of GLT8D2 in ovarian cancer cell lines and OVCAR3 and SKOV3 cancer cell lines was chose for stably overexpressed and knockout GLT8D2 expression (Fig. 2a and Supplementary Fig. 2b). This evidence concerns the gene GLT8D2 and cancer.