This reduction in paclitaxel-induced cell death observed in the GBP2 KO cells was effectively reversed by the knock-in of GBP2 in two independent GBP2 KO cell lines, thus confirming that GPB2 is a key mediator of paclitaxel-induced apoptosis in K562 leukemia cells (Fig. 5f). The gene discussed is GBP2; the disease is leukemia.