In addition, RARA is more abundant in CRH neurons of affective disorder hypothalami [40], where it both upregulates corticotropin-releasing hormone (CRH) expression and blocks glucocorticoid negative feedback on CRH [41], suggesting a link between retinoid TFs and elevated hypothalamic-pituitary-adrenal axis activity in MDD. The gene discussed is CRH; the disease is major depressive disorder.