NR3C1 and major depressive disorder: Altogether, functional SNP enrichment for these TFs’ motifs bolster our confidence in this approach, as (a) detected variation involves TFs known to be expressed in N2As (SREBF); (b) functional variation involves TFs with roles in developing CNS, where disease variants likely act; and (c) that the single-best characterized trigger of MDD (stress) is reflected in enrichment of alterations to NR3C1 motifs.