When examining SNPs with allelic effects in comparison to SNPs with no allelic, drug, or interaction effects, several retinoid receptor motifs were again overrepresented, including those of RXRA, RXRB, RARA, and RARG (Fig. 5A, Supplemental Figure S4), totaling 11 of the 92 allele main effect SNPs analyzed, spanning 10 MDD GWAS loci. This evidence concerns the gene RXRA and major depressive disorder.