CDKAL1 and major depressive disorder: Of 1013 SNPs analyzed, we identified significant allelic TR (Pemp < 0.05) at 76 SNPs (65 from MDD loci; 1 from the control CDKAL1 locus) across 27 of the 40 analyzed GWAS regions, with effects ranging 0.1 to 0.63 (median 0.2) log2 fold-change (Fig. 2B).