When examining SNPs with allelic effects in comparison to SNPs with no allelic, drug, or interaction effects, several retinoid receptor motifs were again overrepresented, including those of RXRA, RXRB, RARA, and RARG (Fig. 5A, Supplemental Figure S4), totaling 11 of the 92 allele main effect SNPs analyzed, spanning 10 MDD GWAS loci. The gene discussed is RXRB; the disease is major depressive disorder.