MMP13 and Hepatic fibrosis: The expression of the MMP-13 gene in other chronic diseases such as liver cirrhosis has been very limited during the recovery phase; however, in the early phase of liver cirrhosis, the transient overexpression of MMP-13 mRNA is induced in macrophages associated with liver scarring during the spontaneous regression of liver fibrosis (hepatic fibrogenesis) [37].