M2-like macrophages promote tumor angiogenesis by producing proangiogenic growth factors (VEGF-A, epidermal growth factor (EGF), and fibroblast growth factor (FGF)), proangiogenic CXC chemokines (CXCL8/IL-8 and CXCL12), and angiogenesis-related factors (TGF-β and TNF-α). This evidence concerns the gene CXCL12 and neoplasm.