ERN1 and Other metabolic disease: Taking into account the involvement of endoplasmic reticulum stress in multiples pathologies among them in inflammatory processes [48] and metabolic disorders [49], we evaluated proteins involved in the main unfolded protein response (UPR) cascades such as inositol-requiring enzyme -1alpha (IRE1α) and eukaryotic initiation factor 2 alpha subunit (eI2Fα).