PSEN1 and Alzheimer disease: Therefore, taking these previous findings into account, and according to the Herrup hypothesis which suggests that peripheral inflammation could be one of the responsible of neuroinflammation associated to neurodegeneration, the aim of our study is to investigate the central and peripheral effects of DXI in the progression of AD and describe the involved mechanisms in APPswe/PS1dE9 (APP/PS1) female mice, familial AD mice model, fed with high fat diet (HFD).