In chronic myeloid leukemia cells, a complex formed by DNM2, Abelson helper integration site-1 (AHI-1) and the fusion oncogene BCR-ABL leads to activation of DNM2 through its phosphorylation by the BCR-ABL tyrosine kinase [32]. The gene discussed is DNM2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.