The regulation of the actin dynamics as the main DNM2 function involved in metastasis was confirmed by the role highlighted for the DNM2-α-actinin 4 complex in the lamellipodia-mediated migration and invadopodia-mediated matrix degradation in pancreatic ductal adenocarcinoma, one of the most aggressive cancer associated with high rates of metastasis [43]. The gene discussed is DNM2; the disease is cancer.