DNM2 and autosomal dominant centronuclear myopathy: Heterozygous mutations in the DNM2 gene are responsible for autosomal dominant forms of three human diseases, i.e. centronuclear myopathy [24], Charcot-Marie-Tooth disease [25], and hereditary spastic paraplegia [26] and one homozygous mutation was shown to cause a lethal congenital syndrome [27].