This study concludes that drastic DNM2 downregulation by siRNA or drug in hepatocellular carcinoma cell lines provides colony formation, migration and invasion of tumor cells by reducing the role of DNM2 as a negative regulator of epidermal growth factor (EGF) signaling through the endocytosis of the EGF receptor [92]. The gene discussed is DNM2; the disease is hepatocellular carcinoma.