HPS4 and lung carcinoma: Additionally, hypermethylated LZTFL1 has been reported to be involved in maintaining cell differentiation [56], ABHD2 was found to control anoikis resistance in HGSOC [57], RNF144A was shown to be a tumor suppressor in governing breast cancer growth and metastasis [58], and HPS4 was shown to alter the functions of the small GTPases Rab32 and Rab38, which are associated with the recurrence of lung cancer [59], 60.