In keeping with these results, among all differentially methylated genes in modulating small GTPase activities, the highest differential DMPs are enriched in their relative gene regions (promoter, gene body, 3′UTR) in relation to TIMP2, RHOH, EphB2, and ARRB1, which have been shown to be tumor suppressors and may be inhibitors of small GTPases (Additional file 2: Table S2) [25–27]. Here, TIMP2 is linked to neoplasm.