We previously developed through cell-SELEX a nuclease resistant 2’Fluoro-pyrimidines (2’F-Py) RNA aptamer, named CL4, capable of binding strongly and specifically to the extracellular domain of human EGFR expressed on cancer cells of glioblastoma (GBM) [19, 20], non-small-cell lung cancer (NSCLC) [21], HER2-positive BC [22, 23] and TNBC [24]. This evidence concerns the gene ERBB2 and non-small cell lung carcinoma.