EGFR and cancer: According to the exquisite selectivity of CL4 for EGFR-positive cancers [25], the ability to actively internalize into target cells via receptor mediated endocytosis [19] and the nearly undetectable toxicity and immune responses in mice [20], this aptamer has been recently used to functionalize nanoparticles for targeted delivery of therapeutic oligonucleotides [26–28] or conventional paclitaxel [29] to TNBC.