In the translocation-associated Ewing’s sarcoma (EWS), myxoid liposarcomas (MLS) or alveolar rhabdomyosarcoma (ARMS), the fusion proteins EF, FUS-DDIT3 or PAX3-FOXO1, respectively, enhance IGF1R expression, a major driver of RAS/AKT/mTOR activation [37]. The gene discussed is EWSR1; the disease is Ewing sarcoma.