We then showed that the miR-326 mimics decreased the protein expression levels of p16INK4A, p21, and p53 (Fig. 6B) and the level of SA-β-gal activity (Fig. 6C) in normoxic OM-MSCs with hemin treatment, whereas miR-326 inhibitors presented the opposite effects in hypoxia OM-MSCs in the condition of hemin treatment (Fig. 6D, E). This evidence concerns the gene TP53 and ocular melanoma.