FTO and Parkinson disease: In addition, Hess et al. [31] found that the inactivation of FTO had a negative impact on the dopamine receptors in a mouse model of PD, thus leading to a reduction in quinpirole-mediated motion function and increased levels of adenosine methylation in the FTO-deficient mice, thus indicating that m6A-related genes regulated the RNA methylation of hub genes to control the dopamine transmission in PD [31].