Kolasa et al. [110] have modeled an ANN with three novel urine markers: urine levels of nuclear matrix protein-22, monocyte chemoattractant protein-1 and urinary intercellular adhesion molecule-1, to predict the diagnosis of bladder cancer and it succeeded in predicting all cancer free patients when the three variables were used as a group. The gene discussed is CCL2; the disease is urinary bladder carcinoma.