SLC5A1 and heart failure: In contrast, SGLT1 was found in hCM 34 , 35 while functionally damaging variants in SGLT1 have been associated with reduced death/heart failure risk.36 We definitively demonstrate, using a large number of human myocardial biopsies and hCM, that SGLT1 is abundantly expressed in the human heart, whereas SGLT2 is barely detectable.