CXCR4 and pancreatic ductal adenocarcinoma: Furthermore, Feig et al. reported that, in a mouse model of pancreatic ductal adenocarcinoma, the administration of an inhibitor against CXCR4, which has been reported to be involved in the suppression of TIL infiltration, induced the rapid accumulation of T lymphocytes in tumors, resulting in a reduction in cancer cell numbers [53].