For example, Group 1 TFs regulated genes significantly associated with acute myeloid leukemia; Group 4 TFs regulated genes that were involved in cancer development, including chronic myeloid leukemia; Group 5 TFs regulated genes significantly associated with cell survival-related functions including cell death, apoptosis, and p53 signaling. The gene discussed is TP53; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.