IGHE and response to penicillin: Penicillin skin testing with a major determinant analog(penicilloyl-polylysine) and minor determinants (benzylpenicilloate,benzylpenilloate, or benzylpenicillin isomers of penicillin) are used forskin test evaluation for IgE-dependent penicillin allergy and can reliablyidentify persons at high risk for IgE-mediated reactions to penicillin(658,660,676).