In the confocal imaging, no signal from the anti-LUCI antibody was observed in cells incubated with NCs and pseudovirus, while strong green fluorescence signals were detected when using no hACE2-expressing 293T cell–derived NVs and pseudovirus, indicating that hACE2 NCs could act as efficient neutralization agents by competitive binding to the S protein and inhibit virus infection (Fig. 1H). This evidence concerns the gene PROS1 and viral infectious disease.