A final example lies in PIEZO1, a mechnosensitive channel that permits the movement of cations across the membrane in response to mechanical forces on the membrane.[47] PIEZO1 has been found to have higher expression levels in high grade gliomas (WHO grade III and IV) than in low grades (WHO grade II), further to this the PIEZO1 gene was downregulated in isocitrate dehydrogenase (IDH) mutant gliomas irrespective of grade. This evidence concerns the gene IDH1 and central nervous system cancer.