KCNC3 and neoplasm: Studies on differentially methylated regions found that the KCNC3 gene was hypermethylated in GBM samples compared to controls which typically indicates silencing of gene expression.[46] Interestingly, another study found that KCNC3 expression was enriched in the GSC compartment but not in the bulk GBM tissue.[41] Taken together, this information suggests that overall tumour expression of KCNC3 is low, but that it is specifically enriched in GSCs which are known to be involved in insidious tumour processes such as local GBM metastasis, resistance and recurrence (see Section 7.4.3).