Since OS and iron metabolism are intimately related, we next investigated which cell types are affected most by OS in SE and TLE-HS brain tissue by examining 4-HNE and HO-1 expression (respective markers of lipid peroxidation and ROS response; a low magnification overview can be found in Online resource 1 g–l). The gene discussed is HMOX1; the disease is histiocytic sarcoma.