Early activation antigen CD69[Cellular response to drug](a) TNFs bind their physiological receptors, and T-cell costimulation(b) Regulation of regulatory T-cell differentiation(c) RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)(d) Autoimmune thyroid disease. This evidence concerns the gene RUNX1 and autoimmune thyroid disease.