Akirin are considered transcription cofactors without catalytic or DNA-binding capability involved in the regulation of signaling pathways such as immune deficiency (IMD), tumor necrosis factor (TNF)/Toll-like receptor (TLR)-nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) (TNF/TLR) and ATP-dependent SWI/SNF-like Brg1/Brm-associated factor (BAF) chromatin remodeling complexes [1,5,11–14]. The gene discussed is TNF; the disease is Immunodeficiency.