Based on 50% tissue culture infectious dose assay of supernatant, productive infection, which indicates viral amplification within infected cells, was elicited by authentic SARS-CoV-2 infection in ACE2-myc3–transduced LSECs; however, it was not elicited in either mock- or L-SIGN-flag–transduced LSECs (Figure 5G). Here, CLEC4M is linked to infection.