Based on our results, it is plausible that SARS-CoV-2 infection of LSECs and LECs through L-SIGN leads to endothelial cell activation and secretion of vWF and FVIII into circulation, which may synergize with ACE2-mediated infection to cause coagulopathy in humans (21, 33, 66). Here, CLEC4M is linked to blood coagulation disease.