Mutations affecting several RBPs, including FUS, TDP-43, hnRNPA1, hnRNPA2B1, matrin-3, and TIA1, are linked to amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), multisystem proteinopathy (MSP), and hereditary inclusion body myopathy (hIBM) phenotypes (8, 9). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.