These findings were then replicated in the B6 into B6D2F1 model of GVHD, where the AMPK-dKO donor facilitated a similar survival advantage in the major MHC mismatch setting (Figure 2G), with concomitant improvements in clinical scores and lower overall weight loss, particularly at later time points (Figure 2, H and I). This evidence concerns the gene PRKAA1 and graft versus host disease.