As a class of ionotropic receptors, NMDA receptors have a wide range of functions in the basic synaptic transmission, neuroplasticity, and neurodegenerative diseases of the central nervous system; the domain of the GRIN2 subunit contains a glutamate binding site (Daw et al., 1993; Fang et al., 2014; Lee et al., 2010). This evidence concerns the gene GPRIN2 and neurodegenerative disease.