In human obesity, UPR pathways' activation, evaluated by CHOP and BiP upregulation, happens together with oxidative stress and inflammation (Banuls et al., 2017; Komura et al., 2010; Sage et al., 2012) this data supports the existence of cross‐linked mechanisms that occur in the kidneys as a result of obesity. The gene discussed is DDIT3; the disease is obesity due to melanocortin 4 receptor deficiency.