At 7 weeks after SE, compared with control group, the levels of LRP4 and MDM4 were significantly increased in epilepsy group (p < .05, Figure 6a and b), while only MDM4 was significantly increased in the DRE group (p < .05, Figure 6a and b), and the levels of LRP4, MDM4, p53, and TMBIM1 had no significant changes in the DRE group compared with the epilepsy group (p > .05, Figure 6a and b). This evidence concerns the gene LRP4 and epilepsy.