At 9 weeks after SE, compared with the control group, the levels of MDM4 and p53 were significantly increased in the epilepsy group (p < .05, Figure 6a and b); the levels of MDM4 were significantly increased in the DRE group (p < .05, Figure 6a and b), and the levels of LRP4, MDM4, p53, and TMBIM1 in the DRE group had no significant difference compared with the epilepsy group (p > .05, Figure 6a and b). Here, LRP4 is linked to epilepsy.