At 6 weeks after SE, compared with the control group, the expression levels of MDM4, p53, and TMBIM1 were significantly increased in the epilepsy group (p < .05, Figure 6a and b), while the levels of LRP4 and MDM4 were significantly decreased (p < .05, Figure 6a and b) but the levels of p53 were significantly increased in the DRE group (p < .05, Figure 6a and b), and the levels of LRP4, MDM4 and TMBIM1 were significantly downregulated in the DRE group compared with the epilepsy group (p < .01, Figure 6 a and b). This evidence concerns the gene LRP4 and epilepsy.