In addition, we monitored the RNA expression levels of cathepsin‐D, cathepsin‐A, glucocerebrosidase, α‐galactosidase, and mucolipin‐1, previously shown to be upregulated in lysosomal diseases (Sardiello et al, 2009), and found all of them to be upregulated in brains of terminally scrapie‐sick mice (Fig 4G). The gene discussed is CTSD; the disease is scrapie.