Tumor susceptibility gene 101 (Tsg101), superoxide dismutase‐2 and Mahogunin‐1, which have been implicated in vacuolating brain diseases including genetic spongiform encephalopathies (He et al, 2003b; Doyotte et al, 2005; Izuo et al, 2015), were unchanged (Appendix Fig S1C). Here, TSG101 is linked to brain disorder.