To the best of our knowledge, our present data are the only in vivo findings published so far through the use of AD rats with a conditional knockdown of astrocytic Grin2a to demonstrate the involvement of the astrocytic NMDA receptor subunit in Aβ‐induced early synaptotoxicity (Skowrońska et al., 2019). This evidence concerns the gene GRIN2A and Alzheimer disease.