GRIN2A and Cognitive impairment: What is more, shGrin2a + Aβ rats showed a significant reduction of preference index (preference index: shGrin2a + Aβ: 0.01 ± 0.01 versus Aβ: 0.09 ± 0.04, p < 0.05), which indicates astrocyte‐specific Grin2a knockdown deteriorates Aβ‐induced cognitive deficit.