Alzheimer’s disease (AD), the most common neurodegenerative disorder, is the leading cause of dementia and is characterized by a progressive neuronal loss with disease-defining Aβ peptide oligomerization and hyperphosphorylated Tau pathologies (Guo et al. 2012; Lane et al. 2018; Tiwari et al. 2019). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.