APP and Alzheimer disease: We find that APP is degraded in an IKKα/β-dependent manner following Metformin treatment, both in SH-SY5Y cells and in APP/PS1 mice, and that phosphorylation of Hsc70 by IKKα/β promotes its interaction with APP and is critical for the alleviation of in vitro APP-induced cytotoxicity and in vivo rescue of both behavioral and molecular AD phenotypes.