In malignant astrocytomas (18 AAs and 58 GBMs) excluding AOs, the median FMISO TBRs for IDH-mutant and IDH-wildtype tumors were 1.70 (IQR 1.44–2.21) and 2.52 (1.86–3.21), respectively (Fig. 1b and Table 2). This evidence concerns the gene IDH2 and astrocytoma (excluding glioblastoma).