Mutations in human cytosolic and mitochondrial NADP-IDH (IDH1 and IDH2, respectively) are frequently identified in a variety of human cancers, such as glioblastoma (GBM) and angioimmunoblastic T cell lymphoma (AITL) (Waitkus et al., 2018; Eniafe and Jiang, 2021). Here, IDH2 is linked to angioimmunoblastic T-cell lymphoma.