Fachel et al. (2013) found that a series of intergene lncRNAs can affect gene expression through cis and trans effects, thereby regulating the occurrence and development of tumors. For example, HOTAIR can recruit PRC2 and LSDL complexes to specific sites through trans-regulation, resulting in methylation or demethylation of specific genes, thereby mediating tumor genesis and metastasis (Wu et al., 2014). LncRNA can also play a role by acting as a competitive binding miRNA between ceRNA and mRNA (Zhou et al., 2014). This evidence concerns the gene HOTAIR and neoplasm.