The results showed that compared with the control group transfected with sgRNA-NT, the proliferation and migration abilities of 786-O and 769-P cells transfected with sgRNA-LINC00944 were significantly decreased, suggesting that knockdown of lncRNA LINC00944 expression could inhibit the proliferation and metastasis of RCC. Here, LINC00944 is linked to renal cell carcinoma.