Based on the existing research, we synthesized and analyzed multiple data sources including the Oncomine, UALCAN, TNMplot, and HPA database, the results showed that the PGK1 mRNA expression was also significantly upregulated in invasive ductal breast carcinoma, intraductal cribriform breast adenocarcinoma, invasive ductal and lobular carcinoma, mixed lobular and ductal breast carcinoma, invasive breast carcinoma, and invasive lobular breast carcinoma using the Oncomine database in-depth analysis. This evidence concerns the gene PGK1 and mixed lobular and ductal breast carcinoma.