As for arginine methylation in FUS, also TDP-43 tendency to acetylation appears different in ALS and FTD contexts, since the acetylated form of TDP-43 is detectable only in ALS spinal specimens and not in brain specimens from FTD-TDP-43 patients (Cohen et al., 2015), suggesting that this PTM might be a valuable specific biomarker to distinguish between these two pathologies. The gene discussed is TARDBP; the disease is frontotemporal dementia.