TARDBP and amyotrophic lateral sclerosis: On the other hand, it is also known that phosphorylated TDP-43 represents one of the predominant components of protein aggregates in ALS and FTD (Hasegawa et al., 2008; Guedes et al., 2017), in which TDP-43 is found phosphorylated in its LCD, mainly on Ser 403/404 and 409/410 (Neumann et al., 2020).