SPI1 and nervous system disorder: Besides that, in this LD block, several variants act as eQTLs/sQTLs in the brain and whole blood, altering the expression of many genes already related to LOAD or other neurological diseases in human or animal studies, such as CELF1 itself, MADD, MYBPC3, NR1H3, NUP160, SPI1, and TOMM40 (Natunen et al., 2013; Karch et al., 2016; Dourlen et al., 2017; Huang et al., 2017; Katsumata et al., 2019; Zhu et al., 2019, 2020; Lutz et al., 2020).