ARHGEF28 and Aarskog-Scott syndrome, X-linked: The modular architectures of faciogenital dysplasia (FGD) family proteins, encompassing FYVE (domain present in Fab1p, YOTB, Vac1p, and EEA1) domains, Dbl homology (DH), and two plectron homology (PH) domains, recognize some phospholipids and proteins such as phosphoinositide (4, 5), phosphatidylinositol 3-phosphate (6), and GTPases, to promote cellular development (7), whose act serves as Rho guanine nucleotide exchange factors (GEFs) (8).