Elevated serum LRG1 levels are associated with various diseases, including different types of cancer (Andersen et al., 2010; Furukawa et al., 2015; Zhang et al., 2018), inflammatory bowel disease (Serada et al., 2012), joint disorders (Ha et al., 2014), and cardiovascular diseases (Watson et al., 2011; Yin et al., 2014; Bos et al., 2017; Xie et al., 2019). The gene discussed is LRG1; the disease is arthropathy.