TP63 and neoplasm: The context-dependent tumor suppressor role of p63 (Flores et al., 2005; Keyes et al., 2006) appears to be largely reflected by the tumor suppressive function of the TAp63 isoform that induces apoptosis and senescence (Gressner et al., 2005; Suh et al., 2006; Guo et al., 2009).