Considering that TDP43 has recently been reported to trigger inflammation by inducing mitochondrial DNA (mtDNA) release to activate cGAS (cyclic guanosine monophosphate-AMP synthase)/STING (The stimulator of interferon genes) in amyotrophic lateral sclerosis (Yu C.H. et al., 2020), we hypothesized whether TDP43 activates p65 phosphorylation in macrophages under oxLDL stimulation is also associated with induction of mtDNA release. Here, TARDBP is linked to amyotrophic lateral sclerosis.