Moreover, TDP43 is demonstrated to locate to mitochondria and trigger mitochondrial DNA release to activate cyclic GMP-AMP synthase (cGAS)/stimulator of type 1 interferon gene (STING) signaling, resulting in induction of inflammatory responses and type I IFN production in amyotrophic lateral sclerosis (Yu C.H. et al., 2020; Kumar and Julien, 2021). Here, CGAS is linked to amyotrophic lateral sclerosis.