In contrast, the combination of a slightly different combination of TFs (Ascl1, NeuroD1, Lmx1a) and miR-218 efficiently programmed striatal astrocytes into functional induced dopaminergic neurons (iDANs), also in a 6-OHDA model of Parkinson’s disease (Rivetti di Val Cervo et al., 2017). This evidence concerns the gene LMX1A and Parkinson disease.