Interestingly, when Neurog2 was expressed in rat mesenchymal stem cells (MSCs) that were transplanted into the striatum 1 day post-middle cerebral artery occlusion (MCAO) stroke in rats, the MSCs transformed into a NPC-like intermediate, and then transdifferentiated into electrically active iNs that could facilitate behavioral recovery (Cheng et al., 2014). The gene discussed is NEUROG2; the disease is Stroke.