CARS1 and cancer: The results demonstrated that, compared to normal tissues, CARS was significantly upregulated in 12 (CHOL, COAD, DLBC, GBM, HNSC, KICH, KIRC, KIRP, LGG, LIHC, PAAD, and PCPG) cancer types and downregulated in 13 (ACC, BRCA, ESCA, LUAD, LUSC, OV, PRAD, SKCM, STAD, TGCT, THCA, UCEC, and UCS) cancer types (P < 0.05; Figure 8A).