Among these, CD8+-inflamed ccRCC with a highly infiltrated level of CD8+ T cell is tightly linked to an increased proportion of higher-grade tumors and worse prognosis, while CD8- inflamed tumors with low infiltration of CD8+ T cell were characterized by an innate immune signature, which showed an increased level of macrophages (Clark et al., 2019). Here, CD8A is linked to nonpapillary renal cell carcinoma.