An analysis involving 530 ccRCC individuals revealed that PD-L1 showed a positive association with the expression levels of most ferroptosis regulators (such as ACSL4, CARS, NCOA4, etc.)but a negative association between HSPB1, MT1G, RPL8, GPX4, and PD-L1 (Figure 3C). This evidence concerns the gene CARS1 and nonpapillary renal cell carcinoma.