ISYNA1 and Alzheimer disease: ino1 encodes inositol-3-phosphate synthase, which is involved in inositol phosphate metabolism and is linked to many human diseases including diabetes, bipolar disorder, and Alzheimer’s disease (McLaurin et al., 1998; Silverstone et al., 2005; Fischbach et al., 2006; Scioscia et al., 2007).