CLN5 and clear cell renal carcinoma: For example, silencing CLN5 (via RNAi) causes G0/1 arrest in HeLa cells, reduces cell number in clear cell renal cell carcinoma, and reduces the viability of HEK293 and primary endothelial cells (Kittler et al., 2007; Gerlinger et al., 2012; Warner et al., 2014; de Rojas-P et al., 2020).