Considering that virus infection may change the miRNA cell repertoire expression (Park et al., 2017; Chirayil et al., 2018; Del Mar Díaz-González et al., 2019), and that miRNA may also regulate gene expression at the transcriptional level (Lytle et al., 2007; Ørom et al., 2008; Place et al., 2008; Zhang et al., 2014), we conducted a bioinformatics analysis to predict miRNA interaction with the PDCD1 -606G>A polymorphic site. The gene discussed is PDCD1; the disease is viral infectious disease.