Besides, the association of PDCD1 -606A allele with the PD-1 expression was strengthened when we specifically evaluated women with high-grade cervical lesions (CIN III); i.e., women carrying the -606A allele at homo- or heterozygosis exhibited higher PD-1 levels in the cervical lesions when compared to women carrying the homozygous -606G allele (GA + AA with the median of 48,117 pixels vs. GG with the median of 8,539 pixels, P = 0.0010) (Figure 4B). This evidence concerns the gene PDCD1 and uterine cervix carcinoma in situ.