In the presence of HPV infection, the high PD-1 levels previously associated with the presence of the -606A allele was not observed anymore (Figures 4D, E); however, the influence of HPV infection on PD-1 levels continue to be observed for high-grade CIN III lesions even being in less magnitude (Figure 4F). Here, PDCD1 is linked to uterine cervix carcinoma in situ.