PDCD1 and uterine cervix carcinoma in situ: However, among carriers of the -606A allele in homo or heterozygosis, the expression of PDCD1 was higher in exfoliative cells of patients exhibiting high-grade CIN III lesions compared to those presenting benign (P = 0.0453) or CIN II (P = 0.0233) lesions (Figure 3D).