TNF and neoplasm: Pro-inflammatory cytokines such as IFN-γ, TNF-α, and IL-12 secreted by classically activated M1-like macrophages recruit Th1 cells and stimulate anti-tumor activity (77), while alternatively activated M2-like TAMs produce anti-inflammatory cytokines such as IL-10 and TGF-β to promote the expansion of Th2/Th17 cells and Tregs (77–79).