ITGAM and neoplasm: Depletion of myeloid cells by administration of Diphtheria Toxin (DT) to CD11b-diphtheria toxin receptor (DTR) mice reversed immune suppression and enabled CD8+ T cell activity, thus preventing PanIN formation in the iKras∗; CD11b-DTR GEMM and inhibiting tumor growth in CD11b-DTR mice transplanted with PDA cells (49).