Moreover, Survival analysis further indicated that seven hub genes (RRM2, KIF23, E2F7, E2F2, E2F1, CDC25A, CCNE1) had impact on HCC patients’ poor OS and DFS except WEE1 (P > 0.05) (Figures 8B and S4). This evidence concerns the gene E2F1 and hepatocellular carcinoma.